Effect of levetiracetam and valproate on late-onset post-traumatic seizures

Abstract Background To compare the preventive effects of levetiracetam and valproate on late-onset post-traumatic seizures in patients with traumatic brain injury (TBI). Methods A total 95 TBI were recruited from 2017 to 2020. They randomized into three groups: (LEV) group ( n = 30) receiving LEV treatment (500 mg, bid, po); 32) sodium mg/d, once daily, control 33) no anti-seizure medication. given corresponding groups within seven days after TBI, administration lasted for one month. The incidence epilepsy adverse events evaluated at 7 12 months post-TBI. Results cumulative incidences late 12-month follow-up LEV, valproate, 3.33%, 12.50% 15.63%, respectively. was significantly lower than those P < 0.05). seizure not different that > Conclusions can reduce seizures, whereas not.